Comment 6 for bug 506320

I'm seeing the same problem pop up here, even after recompiling wine from source as I do every day.

Runes of Magic generates:

  err:winediag:X11DRV_WineGL_InitOpenglInfo Direct rendering is disabled, most likely your OpenGL drivers haven't been installed correctly
  err:d3d_caps:WineD3D_CreateFakeGLContext Can't find a suitable iPixelFormat.
  err:d3d:InitAdapters Failed to get a gl context for default adapter
  err:d3d:WineDirect3DCreate Direct3D9 is not available without opengl

Even though glxinfo | grep "direct rend" results in:

  direct rendering: Yes

glxgears and desktop effects seem to work fine.