Comment 2 for bug 1821867

After doing a restart the interface is down again, hence it's probably more a networkd / systemd issue:

$ ssh ubuntu@hwe0007
ssh: connect to host hwe0007 port 22: No route to host

---

hwe0007 login: ubuntu
ubuntu
Password:

Last login: Wed Mar 27 04:18:31 EDT 2019 from 10.172.194.67 on pts/0
Welcome to Ubuntu Disco Dingo (development branch) (GNU/Linux 5.0.0-7-generic s3
90x)

 * Documentation: https://help.ubuntu.com
 * Management: https://landscape.canonical.com
 * Support: https://ubuntu.com/advantage

ubuntu§hwe0007:ß$ ip a
ip a
1: lo: <LOOPBACK,UP,LOWER_UP> mtu 65536 qdisc noqueue state UNKNOWN group defaul
t qlen 1000
    link/loopback 00:00:00:00:00:00 brd 00:00:00:00:00:00
    inet 127.0.0.1/8 scope host lo
       valid_lft forever preferred_lft forever
    inet6 ::1/128 scope host
       valid_lft forever preferred_lft forever
2: enc600: <BROADCAST,MULTICAST> mtu 1500 qdisc noop state DOWN group default ql
en 1000
    link/ether 02:28:0b:00:00:15 brd ff:ff:ff:ff:ff:ff
ubuntu§hwe0007:ß$

ubuntu§hwe0007:ß$ sudo netplan apply
sudo netplan apply
¬sudo| password for ubuntu: pass4now

ubuntu§hwe0007:ß$

ip a
ip a
1: lo: <LOOPBACK,UP,LOWER_UP> mtu 65536 qdisc noqueue state UNKNOWN group defaul
t qlen 1000
    link/loopback 00:00:00:00:00:00 brd 00:00:00:00:00:00
    inet 127.0.0.1/8 scope host lo
       valid_lft forever preferred_lft forever
    inet6 ::1/128 scope host
       valid_lft forever preferred_lft forever
2: enc600: <BROADCAST,MULTICAST,UP,LOWER_UP> mtu 1500 qdisc fq_codel state UP gr
oup default qlen 1000
    link/ether 02:28:0b:00:00:15 brd ff:ff:ff:ff:ff:ff
    inet 10.245.236.27/24 brd 10.245.236.255 scope global enc600
       valid_lft forever preferred_lft forever
    inet6 fe80::28:bff:fe00:15/64 scope link
       valid_lft forever preferred_lft forever
ubuntu§hwe0007:ß$